学术报告第201425期

报告题目： Wireless  blood pressure monitoring system for animal and human

报告人：王青  研究员

时间：2014年9月29号上午10:00

地点：南一楼中311室

报告人单位:  Centre Hospitalier Universitaire Vaudois/University Hospital of  Lausanne

报告人简介:

 Qing  Wang,   M.D.,  researcher  project   leader,  Division  of   Nephrology  and  Hypertension, University  Hospital/   CHUV, University of Lausanne,   Switzerland; Guest research fellow, Chinese  Hypertension   League  Institute  in   Beijing,  and  adjunct   professor,  Huazhong  University  of  Science   &  Technology  in   Wuhan,  China;  Members   of  American Physiological  Society,   European  Society  of   Cardiology,  and  World   Action  on  Salt   and Health  (WASH);  Overseas   representative  for  the   Annual  Sessions  of   the  11th  National Committee  of   the  Chinese  People's   Political  Consultative  Conference   (CPPCC)  and member of the board  of directors of Beijing Chinese Overseas Friendship Association.

报告摘要: 

Today,  hypertension   affects  approximately  25%   of  the  adult   population  worldwide,  and   its prevalence is predicted to increase by 60% by 2025, when a total of  1.56 billion people may be affected. Hypertension is the most important risk  factor leading to cardiovascular diseases (CVD) and causing 62% stroke and 49%  myocardial infarction (or coronary heart disease). According to WHO report  in 2011, among a total global death of 55  million, 17 million or 30% of death was due to CVD and will rise to 23.4 million  in 2030.  Small  rodent   such as mouse and  rat  are   widely  used  for   investigating  the  pathogenesis   of  Human  hypertension, cardiovascular  diseases,   diabetes,  etc  and   for  developing  new   diagnosis  and  therapeutic strategies. Wireless biosensors  are increasingly being used for improving vital signal monitory system, solving  a wide  variety of medical  and   research  challenges, and  improving research and  medical   quality.  This  requires   innovative  high-precision  micro   technology.  We  have designed  and   generated  an  implantable   telemetric  pressure  device   for  long-term  accurately monitoring of blood pressure (BP)  and heart rate in a free moving small rodent animal (mouse and  rat).   The  telemetric  device   consists  of  a   pressure  sensor,  a   telemetry  chip,  and   an implantable catheter. The prototypes have been proved in mice and  rats. It  can be adapted for  continuously  monitoring  venous   and  arterial  blood   pressure  in  Human.   The  telemetric pressure device  enables for (1)  long-term accurately  monitoring of arterial and venous blood pressure, right ventricular pressure,  and heart rate etc, (2) drug delivery and blood sampling. Further step are (1)  to generate the device with an appropriate data transmission bandwidth and  couple distance for accurate monitoring of high frequency vital signals such as  mouse left ventricular  pressure  etc   and  (2)  for   developing  multi-sensing  monitoring   vital  signals  (BP, ECG,   glucose,  etc)  in   animals  and  patients   with  hypertension,  cardiovascular  diseases, diabetes, and  others.